연구발표논문

Kawasaki Ha, Abe Hab

a.The Life Science Institute Co. Ltd

b.Kudan Clinic


【Abstract】

Purpose
Epigenetics has a critical role in various events in both normal development and human disease. DNA methylation, a major epigenetic

modification, regulates gene expression at the transcriptional level. In this review, to understand epigenetics we focus on DNA

methylation in molecular biology and human disease.

Study selection

We selected 105 reports related to DNA methylation in molecular biology or human disease using PubMed (NCBI) database.

Results
In carcinogenesis, aberrant DNA methylation, such as hypomethylation of the global chromosome and hypermethylation of some

tumor suppressor genes, is observed. In addition, in chronic inflammation caused by Helicobacter pylori infection, some genes are

methylated. DNA methylation has the potential to be a biomarker for cancer diagnosis and a target for cancer therapy.

Conclusion

Elucidating DNA methylation is important for understanding molecular biology and human disease. Further studies of epigenetics

will contribute to applications for diagnosis and therapy in human disease.

• 국제개별화의료학회(지)
Volume 1, Issue 1, July 2012, Pages 7–12