연구발표논문

2011/03/04Kawasaki H, Akiyama S, Hamaya K, Abe H:

Kudan Clinic

Abstract

DNA methylation plays an important role in regulating normal development and tumor genesis. DNA methylation is involved in

epigenetic phenomena without alternation of DNA sequences in genes and regulates gene expression at transcriptional level.

In tumor genesis, aberrations of DNA methylation such as hypomethylation in the global chromosome and hypermethylation \

of some of tumor suppressor genes are observed. Hypermethylation of promoter region on tumor suppressor genes leads to

inactivation of the gene function. Moreover, DNA methylation has potential to be new biomarker of a cancer diagnosis and target

of cancer therapy. This review highlights the role of DNA methylation and cancer.

• 국제저널 통합의료학회(지) vol. 3(1): 36-45, 2011